Two cases of 'cannabis acute psychosis' following the administration of oral cannabis

Autor: M. Appenzeller, Patrice Mangin, Annick Ménétrey, Marie Pin, Laura E. Rothuizen, Marc Augsburger, Thierry Buclin, Bernard Favrat, Christian Giroud
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Adult
Male
Paranoid Disorders
Drug
Marijuana Abuse
medicine.medical_specialty
lcsh:RC435-571
media_common.quotation_subject
medicine.medical_treatment
Administration
Oral
Poison control
Case Report
Marijuana Smoking
Psychoses
Substance-Induced
Psychiatric history
Oral administration
lcsh:Psychiatry
Humans
Medicine
Dronabinol
Tetrahydrocannabinol
Psychiatry
media_common
Acute Disease
Depersonalization/chemically induced
Dronabinol/administration & dosage
Dronabinol/blood
Dronabinol/pharmacology
Hallucinogens/administration & dosage
Hallucinogens/blood
Hallucinogens/pharmacology
Marijuana Abuse/blood
Marijuana Abuse/etiology
Marijuana Smoking/epidemiology
Marijuana Smoking/psychology
Paranoid Disorders/chemically induced
Psychoses
Substance-Induced/blood
Psychoses
Substance-Induced/etiology
biology
business.industry
biology.organism_classification
Nabilone
Psychiatry and Mental health
Depersonalization
Hallucinogens
Cannabis
Cannabinoid
business
medicine.drug
Zdroj: BMC psychiatry, vol. 5, pp. 17
BMC Psychiatry
BMC Psychiatry, Vol 5, Iss 1, p 17 (2005)
Popis: Background Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. Case presentations We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented. Conclusion While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur.
Databáze: OpenAIRE
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