Copper and molybdenum absorption by rats given ammonium tetrathiomolybdate
| Autor: | T.T. El-Gallad, Ian Bremner, G. Wenham, C. F. Mills |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Absorption (pharmacology)
Inorganic chemistry chemistry.chemical_element Kidney Biochemistry Bone and Bones Absorption Inorganic Chemistry chemistry.chemical_compound Animals Tissue Distribution Renal uptake Molybdenum Gastrointestinal tract urogenital system Antagonist Metabolism Ammonium tetrathiomolybdate Copper Rats Quaternary Ammonium Compounds Liver chemistry embryonic structures Nuclear chemistry |
| Zdroj: | Journal of Inorganic Biochemistry. 14:163-175 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/s0162-0134(00)80037-9 |
| Popis: | Previous studies have shown that the tetrathiomolybdate ion [MoS 4 2− ] is a potent antagonist of Cu metabolism. Effects of orally administered MoS 4 2− on the absorption and tissue distribution of 64 Cu in rats have now been investigated. Four or 12 mg Mo/kg diet, when given as MoS 4 2− , strongly inhibited 64 Cu absorption and modified the fate of absorbed Cu, decreasing hepatic and renal uptake but increasing plasma retention of 64 Cu. These effects were not induced by equivalent dietary concentrations of Mo as MoS 4 2− or when S 2− was given as CaS. Clinical and biochemical effects induced by orally administered MoS 4 2− were abolished by increasing dietary concentrations of Cu. Such treatment also inhibited the absorption and tissue retention of 99 Mo derived from 99 MoS 4 2− . Intraperitoneal administration of Cu ameliorated clinical effects attributable to MoS 4 2− but neither inhibited 99 Mo absorption nor the appearance of systemic defects in Cu metabolism. Since the absorption of MoS 4 2− (or its derivatives) from the gastrointestinal tract is inhibited by Cu, it is evident that the site of its action as an antagonist influencing either the absorption or the subsequent metabolic fate of Cu depends upon the ratio Cu/MoS 4 2− in the diet. |
| Databáze: | OpenAIRE |
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