Optogenetic Activation of Dorsal Raphe Serotonin Neurons Rapidly Inhibits Spontaneous But Not Odor-Evoked Activity in Olfactory Cortex
| Autor: | Eran Lottem, Zachary F. Mainen, Magor L. Lorincz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Olfactory system Sensory system Optogenetics Serotonergic 03 medical and health sciences Primary olfactory cortex Mice 0302 clinical medicine Dorsal raphe nucleus Biological Clocks Neuromodulation medicine Animals General Neuroscience Neural Inhibition 01.06. Biológiai tudományok Articles Smell 030104 developmental biology medicine.anatomical_structure Olfactory Cortex Odorants Raphe Nuclei Nerve Net Raphe nuclei Psychology Neuroscience 030217 neurology & neurosurgery Serotonergic Neurons |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| Popis: | Serotonin (5-hydroxytriptamine; 5-HT) is implicated in a variety of brain functions including not only the regulation of mood and control of behavior but also the modulation of perception. 5-HT neurons in the dorsal raphe nucleus (DRN) often fire locked to sensory stimuli, but little is known about how 5-HT affects sensory processing, especially on this timescale. Here, we used an optogenetic approach to study the effect of 5-HT on single-unit activity in the mouse primary olfactory (anterior piriform) cortex. We show that activation of DRN 5-HT neurons rapidly inhibits the spontaneous firing of olfactory cortical neurons, acting in a divisive manner, but entirely spares sensory-driven firing. These results identify a new role for serotonergic modulation in dynamically regulating the balance between different sources of neural activity in sensory systems, suggesting a possible role for 5-HT in perceptual inference.SIGNIFICANCE STATEMENTSerotonin is implicated in a wide variety of (pato)physiological functions including perception, but its precise role has remained elusive. Here, using optogenetic toolsin vivo, we show that serotonergic neuromodulation prominently inhibits the spontaneous electrical activity of neurons in the primary olfactory cortex on a rapid ( |
| Databáze: | OpenAIRE |
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