Phagocytosis: what's on the menu?
| Autor: | Roberto J. Botelho, Charlene E. Lancaster, Victoria E. B. Hipolito, Mauricio R. Terebiznik, Cheuk Y. Ho |
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| Rok vydání: | 2018 |
| Předmět: |
Phagocytic cup
Phagocytosis Receptors Cell Surface Biochemistry Mini review Cell Physiological Phenomena 03 medical and health sciences 0302 clinical medicine Phagosomes Phagosome maturation Animals Humans Molecular Biology Tissue homeostasis 030304 developmental biology 0303 health sciences biology Mechanism (biology) Cell Biology biology.organism_classification Cell biology Immune defence Protozoa 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Biochemistry and cell biology = Biochimie et biologie cellulaire. 97(1) |
| ISSN: | 1208-6002 |
| Popis: | Phagocytosis is an evolutionarily conserved process. In Protozoa, phagocytosis fulfills a feeding mechanism, while in Metazoa, phagocytosis diversified to play multiple organismal roles, including immune defence, tissue homeostasis, and remodeling. Accordingly, phagocytes display a high level of plasticity in their capacity to recognize, engulf, and process targets that differ in composition and morphology. Here, we review how phagocytosis adapts to its multiple roles and discuss in particular the effect of target morphology in phagocytic uptake and phagosome maturation. |
| Databáze: | OpenAIRE |
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