Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy
| Autor: | Aliaskar Hasani, Julia L. Berkowitz, Christina Liu, Diana S. Wolfe, Mohammad Hashim Mustehsan, Claudia Lama von Buchwald, Anna E. Bortnick, Cynthia C. Taub, Shayna Vega |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Peripartum cardiomyopathy Adolescent Cardiomyopathy 030204 cardiovascular system & hematology Article Ventricular Function Left Persistence (computer science) 03 medical and health sciences Ventricular Dysfunction Left Young Adult 0302 clinical medicine Internal medicine medicine Peripartum Period International Statistical Classification of Diseases and Related Health Problems Humans Radiology Nuclear Medicine and imaging Subclinical infection Retrospective Studies Pregnancy 030219 obstetrics & reproductive medicine Ejection fraction business.industry Stroke Volume medicine.disease Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Cardiomyopathies |
| Zdroj: | Echocardiography |
| Popis: | Objectives Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF). Methods We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999-2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. N = 195 charts were reviewed for inclusion/exclusion criteria, n = 53 patients met criteria for PPCM, and of those, n = 13 had a baseline and follow-up echocardiogram suitable for GLS analysis. Results Of those eligible for strain analysis, the mean age was 30 ± 6 years, 46.2% identified as Black and 38.5% as Hispanic/Latina. Baseline LVEF was 30 (25, 35)%, GLS was -13.2 (-14, -7.6)%. At a mean follow-up time of 1.2 ± 0.7 years, 11/13 had persistently mild -15.6 (-16.3, -12.7)%, and 2/13 severely abnormal GLS -7.05 (-7.1, -7.0)%. There was no correlation between baseline GLS and ∆LVEF (r = .014, P = .965). Conclusions Global longitudinal strain is a sensitive method to identify subclinical myocardial dysfunction. In this series of women with PPCM, GLS remained persistently abnormal over time, even if LVEF improved. Future studies should examine the implication of persistently abnormal GLS in PPCM. |
| Databáze: | OpenAIRE |
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