Human bony labyrinth is an indicator of population history and dispersal from Africa

Autor: Marco Milella, Christoph P. E. Zollikofer, John David Weissmann, Toetik Koesbardiati, Gen Suwa, Anna-Sapfo Malaspinas, Carlos S Reyna-Blanco, Tim D. White, Osamu Kondo, Marcia S. Ponce de León
Přispěvatelé: University of Zurich, White, Tim D
Rok vydání: 2018
Předmět:
10207 Department of Anthropology
0301 basic medicine
History
Corrections
Imaging
Human Genome Project
Stabilizing selection
Tomography
History
Ancient

Comparative
bony labyrinth
human dispersals
morphometrics
stabilizing selection
Pediatric
education.field_of_study
Multidisciplinary
300 Social sciences
sociology & anthropology

Ear
Biological Evolution
X-Ray Computed
Anatomy
Comparative

Phenotype
medicine.anatomical_structure
Anatomy
Primates
Cephalometry
Human Migration
Population
Biology
Ancient
Bony labyrinth
03 medical and health sciences
Imaging
Three-Dimensional

Genetics
medicine
Animals
Humans
Inner ear
education
Local adaptation
1000 Multidisciplinary
Phenotypic plasticity
Inner
030104 developmental biology
Ancient DNA
Evolutionary biology
Ear
Inner

Three-Dimensional
Africa
Biological dispersal
Tomography
X-Ray Computed
Zdroj: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 16
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 16, pp. 4128-4133
Proceedings of the National Academy of Sciences
ISSN: 1091-6490
0027-8424
DOI: 10.1073/pnas.1717873115
Popis: The dispersal of modern humans from Africa is now well documented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurred by the effects of local adaptation and in vivo phenotypic plasticity, and that is often deteriorated by postmortem damage to skeletal remains. These complexities raise the question of which skeletal structures most effectively track neutral population history. The cavity system of the inner ear (the so-called bony labyrinth) is a good candidate structure for such analyses. It is already fully formed by birth, which minimizes postnatal phenotypic plasticity, and it is generally well preserved in archaeological samples. Here we use morphometric data of the bony labyrinth to show that it is a surprisingly good marker of the global dispersal of modern humans from Africa. Labyrinthine morphology tracks genetic distances and geography in accordance with an isolation-by-distance model with dispersal from Africa. Our data further indicate that the neutral-like pattern of variation is compatible with stabilizing selection on labyrinth morphology. Given the increasingly important role of the petrous bone for ancient DNA recovery from archaeological specimens, we encourage researchers to acquire 3D morphological data of the inner ear structures before any invasive sampling. Such data will constitute an important archive of phenotypic variation in present and past populations, and will permit individual-based genotype-phenotype comparisons.
Databáze: OpenAIRE