Human bony labyrinth is an indicator of population history and dispersal from Africa
Autor: | Marco Milella, Christoph P. E. Zollikofer, John David Weissmann, Toetik Koesbardiati, Gen Suwa, Anna-Sapfo Malaspinas, Carlos S Reyna-Blanco, Tim D. White, Osamu Kondo, Marcia S. Ponce de León |
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Přispěvatelé: | University of Zurich, White, Tim D |
Rok vydání: | 2018 |
Předmět: |
10207 Department of Anthropology
0301 basic medicine History Corrections Imaging Human Genome Project Stabilizing selection Tomography History Ancient Comparative bony labyrinth human dispersals morphometrics stabilizing selection Pediatric education.field_of_study Multidisciplinary 300 Social sciences sociology & anthropology Ear Biological Evolution X-Ray Computed Anatomy Comparative Phenotype medicine.anatomical_structure Anatomy Primates Cephalometry Human Migration Population Biology Ancient Bony labyrinth 03 medical and health sciences Imaging Three-Dimensional Genetics medicine Animals Humans Inner ear education Local adaptation 1000 Multidisciplinary Phenotypic plasticity Inner 030104 developmental biology Ancient DNA Evolutionary biology Ear Inner Three-Dimensional Africa Biological dispersal Tomography X-Ray Computed |
Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 16 Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 16, pp. 4128-4133 Proceedings of the National Academy of Sciences |
ISSN: | 1091-6490 0027-8424 |
DOI: | 10.1073/pnas.1717873115 |
Popis: | The dispersal of modern humans from Africa is now well documented with genetic data that track population history, as well as gene flow between populations. Phenetic skeletal data, such as cranial and pelvic morphologies, also exhibit a dispersal-from-Africa signal, which, however, tends to be blurred by the effects of local adaptation and in vivo phenotypic plasticity, and that is often deteriorated by postmortem damage to skeletal remains. These complexities raise the question of which skeletal structures most effectively track neutral population history. The cavity system of the inner ear (the so-called bony labyrinth) is a good candidate structure for such analyses. It is already fully formed by birth, which minimizes postnatal phenotypic plasticity, and it is generally well preserved in archaeological samples. Here we use morphometric data of the bony labyrinth to show that it is a surprisingly good marker of the global dispersal of modern humans from Africa. Labyrinthine morphology tracks genetic distances and geography in accordance with an isolation-by-distance model with dispersal from Africa. Our data further indicate that the neutral-like pattern of variation is compatible with stabilizing selection on labyrinth morphology. Given the increasingly important role of the petrous bone for ancient DNA recovery from archaeological specimens, we encourage researchers to acquire 3D morphological data of the inner ear structures before any invasive sampling. Such data will constitute an important archive of phenotypic variation in present and past populations, and will permit individual-based genotype-phenotype comparisons. |
Databáze: | OpenAIRE |
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