Liver metastases: safety and efficacy of detection with superparamagnetic iron oxide in MR imaging
| Autor: | Marie-France Bellin, E. Auberton, D. Khayat, G. Sarfati, J.-J. Duron, Souhil Zaim, J. Grellet |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Iron Iron oxide Contrast Media Metastasis chemistry.chemical_compound medicine Humans Radiology Nuclear Medicine and imaging Magnetite Nanoparticles chemistry.chemical_classification medicine.diagnostic_test Transferrin saturation business.industry Liver Neoplasms Dextrans Oxides Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Mr imaging Ferrosoferric Oxide Liver chemistry Evaluation Studies as Topic Transferrin Serum iron Female business Nuclear medicine Superparamagnetic iron oxide |
| Zdroj: | Radiology. 193:657-663 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.193.3.7972804 |
| Popis: | To evaluate the clinical and biologic safety of superparamagnetic iron oxide (SPIO) as a contrast agent in magnetic resonance (MR) imaging and to assess its efficacy in the detection of liver metastases.Twenty adults with liver metastases underwent MR imaging at 1.5 T before and 1 hour after infusion of SPIO. Four spin-echo (SE) sequences and one gradient-echo (GRE) sequence were used.There were no adverse reactions. Alterations in serum protein, serum iron, transferrin, and ferritin levels and transferrin saturation coefficient were statistically significant. The mean tumor-to-liver contrast-to-noise ratio (C/N) increased markedly with all sequences. The best postcontrast tumor-to-liver contrast was obtained with the GRE sequence (repetition time msec/echo time msec = 300/15). The mean number of apparent lesions detected after administration of SPIO increased by 12 with the proton-density-weighted SE sequences (800/30 and 2,500/30), four with the T2-weighted SE sequence (2,500/90), and seven with the GRE sequence (300/15).SPIO is safe, increases tumor-to-liver C/Ns with some sequences, and improves the detection of liver metastases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|