Patient survival, predictive factors and disease course of severe sepsis in Czech intensive care units: A multicentre, retrospective, observational study
| Autor: | Vladimír Šrámek, Jan Maláska, Milan Adamus, Petr Štourač, Vladimir Cerny, Radovan Uvizl, Jiri Jarkovsky, Martin Matejovic, R Kula, Pavel Ševčík, Ladislav Dušek |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Critical Care assessment lcsh:Medicine septic shoc General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Sepsis Intensive care Internal medicine medicine Clinical endpoint Humans Outpatient clinic Hospital Mortality 030212 general & internal medicine 10. No inequality Severe sepsis Aged Czech Republic Retrospective Studies Aged 80 and over lactate Septic shock business.industry lcsh:R 030208 emergency & critical care medicine Retrospective cohort study Patient survival Middle Aged medicine.disease Shock Septic mortality severe sepsis 3. Good health Surgery Intensive Care Units Female Observational study business |
| Zdroj: | Biomedical Papers, Vol 160, Iss 2, Pp 287-297 (2016) |
| ISSN: | 1804-7521 1213-8118 |
| Popis: | Background: Severe sepsis/septic shock is associated with high mortality. In Central Europe, there is a dearth of information on the prevalence and treatment of severe sepsis. The EPOSS (Data-based Evaluation and Prediction of Outcome in Severe Sepsis) project launched in 2011 was aimed at collecting data on patients with severe sepsis/septic shock. Methods: The EPOSS study processes data from the EPOSS project database, and is a retrospective, multicentre, observational study. This included all consecutive patients aged 18 and over who were admitted to participating ICUs from 1 January 2011 to 5 November 2013 and met the inclusion criteria of severe sepsis/septic shock. The primary endpoint was to analyse the relationship between in-hospital mortality (either in ICU or after discharge from ICU) and the type and number of fulfilled diagnostic and treatment interventions during the first 6 h after the diagnosis of severe sepsis/septic shock. Results: The collected dataset involved 1082 patients meeting the criteria of severe sepsis/septic shock. Following data validation, a final dataset of 897 patients was obtained. The average age of the patient group was 64.7 years; mortality at discharge from EPOSS ICUs was 35.5% and from hospital 40.7%. Of the 10 evaluated diagnostic and treatment interventions within the initial 6 hours of identifying severe sepsis/septic shock (i.e. fulfilment of SSC bundles), four or five diagnostic and treatment interventions were administered to 58.4% patients. Combined diagnostic and treatment interventions associated with the lowest in-hospital mortality were: CVP of ≥8-12 mm Hg & MAP of ≥65 mm Hg & Urine output at ≥0.5 mL/kg/h & Lactate of ≤4.0 mmol/L & Initial lactate measured & Antibiotics in the first hour. Lactate at |
| Databáze: | OpenAIRE |
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