Id proteins in cell growth and tumorigenesis
| Autor: | Hashmat A Sikder, Meghann K Devlin, Shariff Dunlap, Rhoda M. Alani, Byungwoo Ryu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Inhibitor of Differentiation Protein 1
Cancer Research Transgene Apoptosis Biology medicine.disease_cause Malignant transformation Mice Neoplasms Gene expression medicine Gene family Animals Humans Neoplastic transformation Gene Cellular Senescence Genetics Regulation of gene expression Cell Cycle Helix-Loop-Helix Motifs Cell Differentiation Cell Biology Cell biology Repressor Proteins Cell Transformation Neoplastic Gene Expression Regulation Oncology Carcinogenesis Cell Division Transcription Factors |
| Zdroj: | Cancer Cell. 3(6):525-530 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/s1535-6108(03)00141-7 |
| Popis: | Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. The development of knockout and transgenic animal models for many members of the Id gene family has been particularly useful in sorting out the biologic relevance of these genes and their expression during normal development, malignant transformation, and tumor progression. Here we review the current understanding of Id gene function, the biologic consequences of Id gene expression, and the implications for Id gene regulation of cell growth and tumorigenesis. |
| Databáze: | OpenAIRE |
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