Family History of Atrial Fibrillation and Risk of Cardiovascular Events: A Multicenter Prospective Cohort Study

Autor: Daniele Pastori, Danilo Menichelli, Gregory Y.H. Lip, Angela Sciacqua, Francesco Violi, Pasquale Pignatelli, Mirella Saliola, Marco Antonio Casciaro, Greta Rende, Tommasa Vicario, Francesco Del Sole, Tommaso Bucci
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
2019-20 coronavirus outbreak
Heredity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Comorbidity
030204 cardiovascular system & hematology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Sex Factors
atrial fibrillation
death
familiarity
heart diseases
mortality
myocardial infarction
Physiology (medical)
Internal medicine
Atrial Fibrillation
Prevalence
Medicine
Humans
Family
Genetic Predisposition to Disease
030212 general & internal medicine
Myocardial infarction
Prospective Studies
Family history
Prospective cohort study
Cardiovascular mortality
Aged
Aged
80 and over
business.industry
Age Factors
Anticoagulants
Atrial fibrillation
medicine.disease
Prognosis
Pedigree
Italy
Heart Disease Risk Factors
Female
Cardiology and Cardiovascular Medicine
business
Mace
Zdroj: CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
ISSN: 1941-3084
Popis: Background: To investigate the association between family history of atrial fibrillation (AF) with cardiovascular events (CVEs), major adverse cardiac events (MACE), and cardiovascular mortality. Methods: Multicenter prospective observational cohort study including 1722 nonvalvular AF patients from February 2008 to August 2019 in Italy. Family history of AF was defined as the presence of AF in a first-degree relative: mother, father, sibling, or children. Primary outcome was a composite of CVEs including fatal/nonfatal ischemic stroke and myocardial infarction, and cardiovascular death. Second, we analyzed the association with major adverse cardiac event. Results: Mean age was 74.6±9.4 years; 44% of women. Family history of AF was detected in 368 (21.4%) patients, and 3.5% had ≥2 relatives affected by AF. Age of AF onset progressively decreased from patients without family history of AF, compared with those with single and multiple first-degree affected relatives ( P P =0.039), major adverse cardiac event (hazard ratio, 1.917 [95% CI, 1.207–3.045], P =0.006), and cardiovascular mortality (hazard ratio, 2.008 [95% CI, 1.047–3.851], P =0.036). Subgroup analysis showed that this association was modified by age, sex, and prior ischemic heart disease. Conclusions: In a cohort of elderly patients with a high atherosclerotic burden, family history of AF is evident in >20% of patients and was associated with an increased risk for CVEs and mortality. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01882114.
Databáze: OpenAIRE
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