Antimicrobial Activity of Subinhibitory Concentrations of Ciprofloxacin against Pseudomonas aeruginosa as Determined by the Killing Curve Method and the Postantibiotic Effect

Autor:	G G, Zhanel, J, Crampton, S, Kim, L E, Nicolle, R J, Davidson, D J, Hoban
Rok vydání:	1992
Předmět:	Pharmacology Infectious Diseases Oncology Ciprofloxacin Pseudomonas aeruginosa Drug Discovery Pharmacology (medical) Microbial Sensitivity Tests General Medicine
Zdroj:	Chemotherapy. 38:388-394
ISSN:	1421-9794 0009-3157
DOI:	10.1159/000239032
Popis:	This investigation used the postantibiotic effect (PAE) and killing curves to examine the antimicrobial activity of subinhibitory (1/8x, 1/4x and 1/2x MIC) and inhibitory (1x MIC) concentrations of ciprofloxacin against mucoid (M) and nonmucoid (NM) urinary isolates of Pseudomonas aeruginosa. Subinhibitory concentrations (1/8x, 1/4x and 1/2x MIC) of ciprofloxacin produced PAEs with no difference between M and NM strains. For NM strains, those with low MICs (or = 1.0 mg/l) to ciprofloxacin produced significantly longer PAEs than isolates with high MICs (1 mg/l). Killing curve studies demonstrated that subinhibitory concentrations of ciprofloxacin produce little effect (1/8x MIC) or stasis (1/4x and 1/2x MIC) of growth for several hours. Only 1x MIC was bactericidal for several strains. At 1/2x and 1x MIC, bacterial inhibition was greater against NM versus M isolates. The M phenotype of P. aeruginosa reduces killing by ciprofloxacin but not the PAE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3a6edeab00d080309a4dbba2884704 https://doi.org/10.1159/000239032 Zobrazit plný text záznamu