Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C
| Autor: | Dearg S. Brown, Philip S. Jackson, R. Ian Storer, Ian R. Baxendale, Toshiyasu Takemoto, Steven V. Ley |
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| Rok vydání: | 2004 |
| Předmět: |
Aqueous solution
Natural product Molecular Structure Polymers Organic Chemistry Total synthesis Antineoplastic Agents Stereoisomerism General Chemistry Catalysis chemistry.chemical_compound Biological Factors Epothilone C chemistry Aldol reaction Epothilones Reagent Organic chemistry Stereoselectivity Macrolides |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 10(10) |
| ISSN: | 0947-6539 |
| Popis: | The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification. |
| Databáze: | OpenAIRE |
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