A dominant lethal genetic system for autocidal control of the Mediterranean fruitfly
| Autor: | Tarig Dafa'alla, Guoliang Fu, Peng Gong, Kirsty C Condon, Alexandra Hiscox, Luke Alphey, Paul G. Coleman, Neil I. Morrison, Sarah Scaife, Matthew J. Epton, George C Condon, David W Kelly |
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| Rok vydání: | 2005 |
| Předmět: |
Integrated pest management
Heterozygote medicine.medical_specialty Embryo Nonmammalian Microinjections Transgene media_common.quotation_subject Molecular Sequence Data Biomedical Engineering Genes Insect Bioengineering Insect Insect Control Models Biological Applied Microbiology and Biotechnology Animals Genetically Modified Sterile insect technique Transformation Genetic Tephritidae Molecular genetics medicine Animals Crosses Genetic Genes Dominant media_common Genetics biology business.industry fungi Ceratitis capitata Tetracycline biology.organism_classification Biotechnology Mutagenesis Insertional DNA Transposable Elements Trans-Activators Molecular Medicine Genes Lethal Lethality business Plasmids |
| Zdroj: | Nature Biotechnology. 23:453-456 |
| ISSN: | 1546-1696 1087-0156 |
| DOI: | 10.1038/nbt1071 |
| Popis: | The Sterile Insect Technique (SIT) used to control insect pests relies on the release of large numbers of radiation-sterilized insects. Irradiation can have a negative impact on the subsequent performance of the released insects and therefore on the cost and effectiveness of a control program. This and other problems associated with current SIT programs could be overcome by the use of recombinant DNA methods and molecular genetics. Here we describe the construction of strains of the Mediterranean fruit fly (medfly) harboring a tetracycline-repressible transactivator (tTA) that causes lethality in early developmental stages of the heterozygous progeny but has little effect on the survival of the parental transgenic tTA insects. We show that these properties should prove advantageous for the implementation of insect pest control programs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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