Extrapyramidal Side Effects in a Blue and Gold Macaw (Ara ararauna) Treated With Haloperidol and Clomipramine
| Autor: | Simon R. Starkey, Hillary D. Hickam, Julia D. Albright, James K. Morrisey, Mary J. Lynch |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Clomipramine
Haloperidol Decanoate Psittaciformes Macaw Basal Ganglia Diseases Extrapyramidal symptoms medicine Haloperidol Animals Small Animals Dystonia Ara ararauna biology Bird Diseases business.industry Diphenhydramine General Medicine biology.organism_classification medicine.disease Anesthesia Dopamine Antagonists Female medicine.symptom business Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Journal of Avian Medicine and Surgery. 22:234-239 |
| ISSN: | 1082-6742 |
| DOI: | 10.1647/2007-037.1 |
| Popis: | A diagnosis of adverse extrapyramidal symptoms (EPS) was reached in a 14-year-old female blue and gold macaw (Ara ararauna) that presented with disseminated dystonia (manifesting as pacing, head bobbing, and circling), intermittent ataxia, and coarse-muscle tremors of 60 hours duration. The patient had been treated 23 days previously with haloperidol decanoate (1.7 mg/kg IM once), and for 3 days before hospitalization with clomipramine HCl at a prescribed dosage of 3.9 mg/kg PO q12h. The patient was treated with supportive care, a gradual reduction in the clomipramine dose, and intramuscular and oral diphenhydramine (2 mg/kg q12h). As commonly observed in human patients with drug-induced EPS, a dramatic resolution of clinical signs was observed within 2 hours after the first intramuscular administration of diphenhydramine. It is recommended that EPS be considered in macaws experiencing neurologic signs secondary to clomipramine administration and, in particular, in those treated concurrently or previously with haloperidol. |
| Databáze: | OpenAIRE |
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