Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms
| Autor: | Zheng Huang, Hanne Mørck Nielsen, Tongchang Zhou, Yi Sun, Feng Wan, Tao Zheng, Yuan Yuan, Sylvia Natalie Kłodzińska, Claus Sternberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Biocompatibility
Photothermal Therapy Nanoparticle Nanotechnology 02 engineering and technology macromolecular substances Bacterial growth Azithromycin 010402 general chemistry 01 natural sciences Biomaterials Carbon quantum dots chemistry.chemical_compound Glycols Colloid and Surface Chemistry Polylactic Acid-Polyglycolic Acid Copolymer Quantum Dots Tobramycin medicine Glycolic acid Drug Carriers Biofilm technology industry and agriculture Photothermal therapy 021001 nanoscience & nanotechnology Carbon 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Glycolates PLGA chemistry Bacterial biofilms Biofilms PLGA nanoparticles Chemo-photothermal therapy Nanoparticles 0210 nano-technology medicine.drug |
| Zdroj: | Huang, Z, Zhou, T, Yuan, Y, Natalie Kłodzińska, S, Zheng, T, Sternberg, C, Mørck Nielsen, H, Sun, Y & Wan, F 2020, ' Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms ', Journal of Colloid and Interface Science, vol. 577, pp. 66-74 . https://doi.org/10.1016/j.jcis.2020.05.067 |
| DOI: | 10.1016/j.jcis.2020.05.067 |
| Popis: | Bacterial biofilm represents a protected mode of bacterial growth that significantly enhances the resistance to antibiotics. Poly lactic-co-glycolic acid (PLGA)-based nanoparticle delivery systems have been intensively investigated to combat the bacterial biofilms-associated infections. However, some drawbacks associated with current PLGA-based nanoformulations (e.g. the relatively low drug loading capability, premature burst release and/or incapability of on-demand release of cargos at the site of action) restrict the transition from the lab research to the clinical applications. One potent strategy to overcome the above-mentioned limitations is exploiting the unique properties of carbon quantum dots (CQDs) and combining CQDs with the conventional PLGA nanoparticles. In the present study, the CQDs were innovatively incorporated into PLGA nanoparticles by using a microfluidic method. The resulting CQD-PLGA hybrid nanoparticles presented good loading capability of azithromycin (a macrolide antibiotic, AZI) and tobramycin (an aminoglycoside antibiotic, TOB), and stimuli-responsive release of the cargos upon laser irradiation. Consequently, AZI-loaded CQD-PLGA hybrid nanoparticles showed chemo-photothermally synergistic anti-biofilm effects against P. aeruginosa biofilms. Additionally, the CQD-PLGA hybrid nanoparticles demonstrated good biocompatibility with the eukaryotic cells. Overall, the proof-of-concept of CQD-PLGA hybrid nanoparticles may open a new possibility in chemo-photothermal therapy against bacterial biofilms. |
| Databáze: | OpenAIRE |
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