Consequences of semen inflammation and lipid peroxidation on fertilization capacity of spermatozoa in in vitro conditions
| Autor: | Monika Fraczek, Anna Szumala-Kakol, Leszek Pawelczyk, Piotr Jedrzejczak, Grazyna Taszarek-Hauke, Maciej Kurpisz |
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| Rok vydání: | 2005 |
| Předmět: |
Infertility
Adult Male medicine.medical_specialty Urology Endocrinology Diabetes and Metabolism medicine.medical_treatment Semen Fertilization in Vitro Biology medicine.disease_cause Thiobarbituric Acid Reactive Substances Lipid peroxidation Cohort Studies chemistry.chemical_compound Human fertilization Internal medicine Malondialdehyde medicine Humans Prospective Studies In vitro fertilisation Pronucleus Estradiol Interleukin-8 medicine.disease Oxidative Stress Endocrinology Reproductive Medicine chemistry embryonic structures Oocytes Female Lipid Peroxidation Oxidative stress |
| Zdroj: | International journal of andrology. 28(5) |
| ISSN: | 0105-6263 |
| Popis: | A body of data exists on reactive oxygen species (ROS) release, however, no direct correlation was found between the oxidative stress and infertility. The aim of the study was to measure semen oxidative stress and its correlation with classical in vitro fertilization (IVF) rate. A prospective study in academic non-profit institution where 79 infertile couples were subjected to IVF programme was conducted. Two infertile groups were discriminated according to the pronuclei presence in IVF. The main outcome measure (pronuclei presence) was then correlated with lipid peroxidation product in semen (ROS effect). Although the average IL-8 levels and malondialdehyde (MDA) content in semen did not differ between the studied subgroups (successful vs. non-successful fertilization), a statistically significant negative correlation was found between MDA level and fertilization rate in performed regression analysis. Thus we may suggest that MDA levels in seminal plasma may have prognostic value for IVF success. |
| Databáze: | OpenAIRE |
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