Identifying traumatic brain injury in patients with isolated head trauma: are arterial lactate and base deficit as helpful as in polytrauma?
| Autor: | Kristin Carmody, Michael Lucchesi, Mridul Kumar, Lekha Shah, Yiju Liu, Samara Soghoian, Richard Sinert, Shahriar Zehtabchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Traumatic brain injury Acid-Base Imbalance Critical Care and Intensive Care Medicine Head trauma Cohort Studies Predictive Value of Tests medicine Humans Lactic Acid Prospective Studies Prospective cohort study business.industry Head injury Glasgow Coma Scale General Medicine medicine.disease Polytrauma nervous system diseases Surgery ROC Curve Anesthesia Predictive value of tests Brain Injuries Emergency Medicine Injury Severity Score Original Article Female business Biomarkers |
| Popis: | Background: Increase in lactate (LAC) within the central nervous system after head trauma is an established marker of traumatic brain injury (TBI). Objective: To investigate the utility of arterial base deficit (BD) and LAC in identifying TBI in patients with isolated head injury (IHI). Materials and methods: TBI was defined as Glasgow Coma Scale ⩽8, head Abbreviated Injury Severity Score >2 or brain haematoma on CT scan. Patients were divided into two groups: IHI with and without TBI. Data were reported as means (SDs). 131 patients with IHI were studied (mean (SD) age 39 (19) years, 78% male). Results: 17% of the patients sustained TBI. The mean differences for arterial BD (0.65 mmol/l, 95% CI −0.8 to 2.1) and LAC (0.34 mmol/l, 95% CI −0.7 to1.4) in patients with and without TBI were not significant. Analysis of receiver operating characteristic curves confirmed that arterial BD and LAC were unable to detect TBI in patients with IHI. Conclusion: Arterial BD and LAC are poor predictors of TBI in isolated head trauma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|