Pergolide as Adjuvant Therapy to Amisulpride in the Treatment of Negative and Depressive Symptoms in Schizophrenia
| Autor: | U. Pfüller, Matthias Weisbrod, K Göhring, Stefan Kaiser, Daniela Roesch-Ely, M Burlon, P Gruschka |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Paranoid schizophrenia medicine.medical_specialty Depressive Disorder/diagnosis/drug therapy/psychology Comorbidity Receptors Dopamine D1/agonists Dopamine Agonists/administration & dosage Antipsychotic Agents/administration & dosage Internal medicine mental disorders medicine Adjuvant therapy Humans Sulpiride/administration & dosage/analogs & derivatives Pharmacology (medical) Amisulpride Depressive symptoms Psychiatric Status Rating Scales Schizophrenia Paranoid/diagnosis/drug therapy/psychology Pergolide business.industry Pergolide/administration & dosage General Medicine medicine.disease Psychiatry and Mental health Institutional repository Treatment Outcome Frontal Lobe/drug effects Receptors Dopamine D2/agonists Schizophrenia Anesthesia Drug Therapy Combination Hallucinations/diagnosis/drug therapy/psychology business Neural Pathways/drug effects medicine.drug Psychopathology |
| Zdroj: | Pharmacopsychiatry, Vol. 39, No 3 (2006) pp. 115-116 |
| ISSN: | 1439-0795 0176-3679 |
| DOI: | 10.1055/s-2006-941488 |
| Popis: | Negative and cognitive symptoms of schizophrenia are associated with a hypodopaminergic state in the frontal cortex and do not respond to neuroleptics equally well as positive symptoms. Therefore pharmacological strategies, which increase dopamine metabolism in the mesocortical pathways, may prove beneficial to ameliorate these symptoms. We report on a case of a patient with paranoid schizophrenia, who still presented negative and depressive symptoms during treatment with amisulpride for more than 6 weeks. We prescribed pergolide (a mixed D1/D2 agonist) as adjuvant therapy to treat these symptoms. The patient showed an improvement of global psychopathology, decrease of negative and depressive symptoms, while no changes in positive symptoms nor EPS were present. For this patient, the adjuvant therapy of pergolide to amisulpride constituted a valid pharmacological approach to treat negative and depressive symptoms of schizophrenia, without increasing positive symptoms. |
| Databáze: | OpenAIRE |
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