Multiplication product of Model for End-stage Liver Disease and Donor Risk Index as predictive models of survival after liver transplantation
| Autor: | Abed Khalaileh, Subhi Harkrosh, Samir Abu Gazala, Richard Nakache, Rifaat Safadi, Eytan Mor, Yakob Nowotny, Tawfik Khoury, H. Merhav, Mohamad Massarwa |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty medicine.medical_treatment Economic shortage Liver transplantation Risk Assessment Donor Selection End Stage Liver Disease 03 medical and health sciences Liver disease 0302 clinical medicine Model for End-Stage Liver Disease Quality of life Predictive Value of Tests Risk Factors Internal medicine Risk index medicine Humans Israel Aged Retrospective Studies Hepatology business.industry Graft Survival Gastroenterology Middle Aged medicine.disease Liver Transplantation Transplantation Survival Rate Treatment Outcome 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology Female business |
| Zdroj: | European journal of gastroenterologyhepatology. 31(9) |
| ISSN: | 1473-5687 |
| Popis: | BACKGROUND Liver transplantation (LT) is the treatment of choice for most end-stage liver diseases. This treatment increases survival rates and improves quality of life. Because of the shortage of organ donors, as opposed to waiting patients, the need to optimize the matching of donors to recipients for maximum utility is crucial. AIM The aim of this study was to examine a predictive model based on the combination of donor and recipient risk factors using the liver Donor Risk Index (DRI) and recipient Model of End-stage Liver Disease (MELD) to predict patients' survival following LT. PATIENTS AND METHODS The charts of 289 adult primary LT patients, who had undergone transplantation in Israel between 2010 and 2015, were studied retrospectively using prospectively gathered data. RESULTS Two variables, DRI and MELD, were found to significantly affect post-transplant patient survival. DRI negatively affected survival in a continuous fashion, whereas MELD had a significantly negative effect only at MELD more than 30. Both female sex and the presence of hepatocellular carcinoma were associated with increased patient survival. CONCLUSION According to our findings, the model described here is a novel prediction tool for the success of orthotopic LT and can thus be considered in liver allocation. |
| Databáze: | OpenAIRE |
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