Adh n5: A temperature-sensitive mutant at the Adh locus in Drosophila
| Autor: | Charles L. Vigue, William Sofer |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Aging
Hot Temperature Time Factors Mutant Alcohol Locus (genetics) Biochemistry chemistry.chemical_compound Drug Stability Species Specificity Ethanol poisoning Genetics Animals Molecular Biology Ecology Evolution Behavior and Systematics Alcohol dehydrogenase Ethanol biology Homozygote fungi Temperature Chromosome Mapping General Medicine Hydrogen-Ion Concentration biology.organism_classification Temperature-sensitive mutant Alcohol Oxidoreductases Kinetics Drosophila melanogaster Genes chemistry Mutation biology.protein Structural locus |
| Zdroj: | Biochemical Genetics. 11:387-396 |
| ISSN: | 1573-4927 0006-2928 |
| DOI: | 10.1007/bf00486412 |
| Popis: | Individuals of an alcohol dehydrogenase-negative strain of Drosophila melanogaster designated Adh n5 are resistant to ethanol poisoning at low but not at high temperatures. The basis for this behavior is that Adh n5 flies contain a mutant form of alcohol dehydrogenase which is less heat stable than that of wild-type flies. The mutation in Adh n5 maps at, or very close to, the presumptive structural locus and is not complemented by any of 11 other alcohol dehydrogenase-null mutants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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