Usnic Acid Potassium Salt: Evaluation of the Acute Toxicity and Antinociceptive Effect in Murine Model
| Autor: | Emerson Peter da Silva Falcão, Diego J.R. da Silva, Eugênia C. Pereira, Nicodemos Teles de Pontes Filho, Mônica Cristina Barroso Martins, Maria Helena Madruga Lima Ribeiro, Mônica Camelo Pessoa de Azevedo Albuquerque, João Ricardhis Saturnino de Oliveira, Marcos André Cavalcanti Bezerra, Janaína V. dos Anjos, Vera Lúcia de Menezes Lima, Mario Ribeiro de Melo-Júnior, José Guedes da Silva Júnior, André de Lima Aires, Hallysson Douglas Andrade de Araújo, Nicácio Henrique da Silva |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Potassium
Molecular Conformation Drinking Behavior Pharmaceutical Science chemistry.chemical_element Pharmacology lichen Article Analytical Chemistry lcsh:QD241-441 Mice 03 medical and health sciences chemistry.chemical_compound Acetic acid 0302 clinical medicine lcsh:Organic chemistry Oral administration Drug Discovery Toxicity Tests Acute medicine Animals soluble drug Cladonia substellata Physical and Theoretical Chemistry Benzofurans 030304 developmental biology toxicological survey Analgesics 0303 health sciences Behavior Animal Chemistry Cholesterol Organic Chemistry Usnic acid Feeding Behavior antinociceptive activity (phase I and II) Acute toxicity Disease Models Animal Organ Specificity Chemistry (miscellaneous) Toxicity histopathology Molecular Medicine Female medicine.symptom usnic acid derivatives Weight gain 030217 neurology & neurosurgery |
| Zdroj: | Molecules, Vol 24, Iss 11, p 2042 (2019) Molecules Volume 24 Issue 11 |
| ISSN: | 1420-3049 |
| Popis: | To obtain usnic acid potassium salt (PS-UA), the usnic acid (UA) was extracted and purified from the lichen Cladonia substellata, and modified to produce PS-UA. The structure was determined by 1H-NMR, IR and elemental analysis, ratified through computational models, as well as identification the site of K+ insertion in the molecule. Antinociceptive activity was detected through contortions in mice induced by acetic acid and formalin (phases I and II) after treatments with 10 and 20 mg/kg of PS-UA, indicating interference in both non-inflammatory and inflammatory pain. After oral administration at doses of 500, 1000 and 2000 mg/kg, no deaths of mice with treatments below 2000 mg/kg were observed. Except for body weight gain, food and water consumption decreased with treatments of 1000 and 2000 mg/kg, and the number of segmented leukocytes was higher for both treatments. Regarding serum levels, cholesterol and triglycerides decreased, however, there was an increase in hepatic transaminases with both treatments. Liver and kidney histological changes were detected in treatments of 2000 mg/kg, while the spleen was preserved. The PS-UA demonstrated antinociceptive activity while the acute toxicity at the concentration of 2000 mg/kg was the only dose that presented morphological changes in the liver and kidney. |
| Databáze: | OpenAIRE |
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