T Cell Reactivity against Mycolyl Transferase Antigen 85 ofM. tuberculosisin HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections

Autor: Pascal Launois, Eliane Bourreau, Kris Huygen, Claire Farber, Pierre Couppié, Jean Paul Van Vooren, Annie Drowart
Rok vydání: 2011
Předmět:
HIV Infections -- complications -- immunology -- virology
Mycobacterium tuberculosis -- immunology
T-Lymphocytes
HIV Infections
Disease
Lymphocyte Activation
Belgium
Immunology and Allergy
Interferon gamma
AIDS-Related Opportunistic Infections/immunology
AIDS-Related Opportunistic Infections/microbiology
Acyltransferases/immunology
Antigens
Bacterial/immunology
French Guiana
HIV/physiology
HIV Infections/complications
HIV Infections/immunology
Humans
Immunologic Memory
Interferon-gamma/metabolism
Lymphocyte Activation/immunology
Mycobacterium Infections/complications
Mycobacterium Infections/immunology
Mycobacterium tuberculosis/immunology
T-Lymphocytes/immunology
Tuberculin Test
Tuberculosis/complications
Tuberculosis/immunology
Tuberculosis
Pulmonary/complications
Tuberculosis
Pulmonary/immunology
Mycobacterium Infections -- complications -- immunology
biology
Tuberculosis -- complications -- immunology -- microbiology
General Medicine
Sciences bio-médicales et agricoles
Lymphocyte Activation -- immunology
Acyltransferases -- immunology
Interferon-gamma -- metabolism
medicine.anatomical_structure
medicine.drug
lcsh:Immunologic diseases. Allergy
Tuberculosis
HIV -- physiology
Article Subject
AIDS-Related Opportunistic Infections
T cell
Immunology
AIDS-Related Opportunistic Infections -- immunology -- microbiology
Tuberculosis
Pulmonary -- complications -- immunology
Mycobacterium tuberculosis
Interferon-gamma
Antigen
Antigens
Bacterial -- immunology
medicine
Tuberculosis
Pulmonary
Antigens
Bacterial
Mycobacterium Infections
business.industry
HIV
biology.organism_classification
medicine.disease
Virology
Clinical Study
Nontuberculous mycobacteria
T-Lymphocytes -- immunology
lcsh:RC581-607
business
Acyltransferases
Zdroj: Clinical and Developmental Immunology
Clinical and Developmental Immunology, Vol 2011 (2011)
Clinical & developmental immunology, 2011
Clinical and Developmental Immunology, vol. 2011, pp. 1-10
ISSN: 1740-2530
1740-2522
Popis: The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.
Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
info:eu-repo/semantics/published
Databáze: OpenAIRE
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