Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium
| Autor: | Andrei Glinka, Hajo Delius, Claudia Blumenstock, Christof Niehrs |
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| Rok vydání: | 1996 |
| Předmět: |
Embryology
Mesoderm animal structures Time Factors Xenopus Xenopus Proteins Epithelium Transforming Growth Factor beta medicine Animals RNA Messenger Noggin Cloning Molecular In Situ Hybridization Body Patterning Glycoproteins Genetics Embryonic Induction biology biology.organism_classification Embryonic stem cell Cell biology Transplantation Wnt Proteins medicine.anatomical_structure embryonic structures Chordin Receptors Transforming Growth Factor beta Biomarkers Developmental Biology Transforming growth factor |
| Zdroj: | Mechanisms of development. 60(2) |
| ISSN: | 0925-4773 |
| Popis: | The epithelium of the Spemann organizer plays an important role in embryonic axis formation and transplantation experiments have shown that epithelial organizer cells have potent axis-inducing potential. Known axis-inducing molecules like noggin and chordin are not expressed in the epithelium and cannot account for its inductive properties. Xwnt-11 is expressed in the epithelium but has only poor dorsalizing activity. In an expression screen for genes that are able to functionally cooperate with Xwnt-11 we have identified a cDNA encoding Xenopus nodal-related 3 (Xnr3), a member of the TGF-β family, coexpressed with Xwnt-11 in the organizer epithelium. Xwnt-11 and Xnr3 act highly cooperatively in inducing secondary embryonic axes and dorsalizing ventral mesoderm. Xwnt-11 Xnr3 interfere with BMP signalling without themselves inducing chordin or noggin. The results indicate that induction by the organizer epithelium may result from the combinatorial action of instructive Xnr3 and permissive Xwnt-11 signalling. |
| Databáze: | OpenAIRE |
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