Prognostic significance of the albumin-to-globulin ratio for upper tract urothelial carcinoma
| Autor: | Manami Kinjo, Tsuyoshi Yamaguchi, Mio Samejima, Takatsugu Okegawa, Yu Nakamura, Naoki Ninomiya, Hiroshi Fukuhara, Shogo Miyagawa, Mitsuhiro Tambo, Kazuki Masuda, Shota Omura, Satoru Taguchi, Ryuki Matsumoto, Eiji Higashihara |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Urology 030232 urology & nephrology lcsh:RC870-923 Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Pathological Serum Albumin Aged Retrospective Studies Carcinoma Transitional Cell Receiver operating characteristic Albumin-to-globulin ratio business.industry Proportional hazards model Ureteral Neoplasms Hazard ratio Radical nephroureterectomy AGR Retrospective cohort study General Medicine Biomarker Prognosis lcsh:Diseases of the genitourinary system. Urology Kidney Neoplasms Survival Rate Reproductive Medicine Upper tract urothelial carcinoma 030220 oncology & carcinogenesis Biomarker (medicine) T-stage Female Serum Globulins business REMARK Research Article |
| Zdroj: | BMC Urology, Vol 20, Iss 1, Pp 1-7 (2020) BMC Urology |
| ISSN: | 1471-2490 |
| DOI: | 10.1186/s12894-020-00700-8 |
| Popis: | Background Although the albumin-to-globulin ratio (AGR) is a promising biomarker for various malignancies, few studies have investigated its prognostic significance for upper tract urothelial carcinoma (UTUC). Methods This retrospective study conformed to the REporting recommendations for tumour MARKer prognostic studies (REMARK) guideline. We reviewed 179 patients with UTUC who underwent radical nephroureterectomy at our institution between 2008 and 2018. Associations of preoperative clinicopathological factors, including the AGR, with cancer-specific survival (CSS) and overall survival (OS) were assessed. The Cox proportional hazards model was used for univariate and multivariable analyses. AGR was dichotomized as Results During a median follow-up of 34 months after surgery, 37 patients died from UTUC and 13 died of other causes. The preoperative AGR significantly correlated with pathological T stage, pathological N stage, and adjuvant chemotherapy. Multivariate analyses demonstrated that a decreased (P P Conclusions Preoperative AGR |
| Databáze: | OpenAIRE |
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