| Autor: |
T.A.W. Splinter, H.E. Gall, A.A.M. Hart, I. Klein, Jan B. Vermorken, H.M. Pinedo, W.J.F. van der Vijgh |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Therapeutic Drug Monitoring. 8:264-268 |
| ISSN: |
0163-4356 |
| DOI: |
10.1097/00007691-198609000-00004 |
| Popis: |
Total platinum kinetics were studied after the administration of two formulation products of cisplatin: the lyophilized form and a ready-to-use solution. Twelve patients received both preparations during two successive cycles in a randomized crossover study. Platinum concentrations in plasma and urine were measured by atomic absorption spectrometry. Data were analyzed by means of a mixed-effect analysis of variance. Areas under the concentration-time curves up to 96 h were increased (p = 0.026) and slopes of the elimination phase were decreased (p = 0.035) during cycle 2 when compared with cycle 1. However, no difference in these two parameters was observed when comparing the two formulations. Three-day urinary platinum excretion was not related to either the treatment cycle or the formulation used. Because of its convenience of use and reduced risk of aerosolization, the ready-to-use formulation seems preferable. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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