Polymorphic debrisoquin metabolism in a turkish population
| Autor: | Nursabah E. Basci, S. Oguz Kayaalp, Atila Bozkurt, Ahmet Sayal, Askin Isimer |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Pharmacology Turkish population Polymorphism Genetic Adolescent Turkey Debrisoquin Physiology Urine Metabolism Biology chemistry.chemical_compound Phenotype Debrisoquine chemistry Humans Debrisoquin Sulfate Female Pharmacology (medical) Oxidation-Reduction Chromatography High Pressure Liquid Pharmacogenetics |
| Zdroj: | ResearcherID |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1994.48 |
| Popis: | Debrisoquin hydroxylation polymorphism was studied in 326 unrelated healthy Turkish volunteers. Debrisoquin sulfate (10 mg) was administered to subjects, and debrisoquin and 4-hydroxydebrisoquin were determined in the 0- to 8-hour urine samples. Debrisoquin oxidation was polymorphic, with 11 subjects (3.37%; 95% confidence interval, 1.69% to 6.07%) phenotyped as poor metabolizers. The metabolic ratio between debrisoquin and 4-hydroxydebrisoquine in 8-hour urine samples ranged from 0.02 in extensive metabolizers to 263.8 in poor metabolizers. The proportion of poor metabolizers was found to be in the range observed in the other white populations studied. Clinical Pharmacology and Therapeutics (1994) 55, 399–401; doi:10.1038/clpt.1994.48 |
| Databáze: | OpenAIRE |
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