Changes in proteasome chymotrypsin-like activity during the development of human mammary and thyroid carcinomas
| Autor: | E. B. Abramova, Yu. V. Lyupina, I. V. Kondakova, Rodoman Gv, Elena M. Slonimskaya, Yu. V. Bogomyagkova, Pavel A. Erokhov, I. R. Sumedi, E. L. Choinzonov, T. M. Astakhova, A. S. Plekhanova, N. P. Sharova, Kuznetsov Na, E. E. Shashova |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Proteasome Endopeptidase Complex Thyroid Gland Breast Neoplasms Biology General Biochemistry Genetics and Molecular Biology Thyroid carcinoma Mammary carcinoma Bortezomib Internal medicine medicine Chymotrypsin Humans Chymotrypsin like Breast Thyroid Neoplasms Stage (cooking) Neoplasm Metastasis Thyroid tumors Neoplasm Staging General Medicine Boronic Acids Proteasome activity Endocrinology Proteasome Drug Resistance Neoplasm Pyrazines Time course Cancer research Female |
| Zdroj: | Bulletin of experimental biology and medicine. 156(2) |
| ISSN: | 1573-8221 |
| Popis: | Changes in the proteasome chymotrypsin-like activity in mammary and thyroid carcinomas in comparison with the adjacent tissue were studied at stages T(1-4)N(0-3)M(0) and T(2-3)N(0-1)M(0), respectively. The activities changed in a wave-like manner over the course of mammary carcinoma growth in cases with and without metastases. The minimum increment of the activity in the tumor was recorded during the T(2)N(0) stage in the absence of local metastases. The increment of the activity reached the peak in N(1) tumors of the same size with metastases. The activities in the tumor and adjacent tissues virtually did not differ during the T(3-4)N(1-3) stages. The time course of proteasome activity changes in thyroid tumors of the studied stages was similar to that in mammary carcinoma. The results can be used for development of methods for evaluating the aggressiveness of mammary and thyroid tumors. |
| Databáze: | OpenAIRE |
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