Development of a Transdermal Patch of Methadone: in Vitro Evaluation Across Hairless Mouse and Human Cadaver Skin
| Autor: | Tapash K. Ghosh, Alireza Bagherian |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Narcotics
Transdermal patch Skin Absorption Pharmaceutical Science In Vitro Techniques Pharmacology Administration Cutaneous Loading dose Excipients Mice medicine Animals Humans Dimethyl Sulfoxide Human cadaver Mice Hairless integumentary system Chemistry Azepines General Medicine Permeation In vitro Hairless Methadone Azone medicine.drug Biomedical engineering |
| Zdroj: | Pharmaceutical Development and Technology. 1:285-291 |
| ISSN: | 1097-9867 1083-7450 |
| DOI: | 10.3109/10837459609022597 |
| Popis: | A 3-day monolithic polyacrylate adhesive dispersion type delivery system containing methadone was fabricated and in vitro permeation through hairless mouse and human cadaver skins was conducted. The effect of skin permeation enhancers was also investigated. Skin permeation rate across human cadaver skin was found to be lower than that of hairless mouse. Skin permeation profiles across both types of skins showed a membrane permeation controlled cumulative amount permeated (Q) versus time (t) relationship. Skin permeation rate was found to be dependent on both adhesive film thickness and loading dose of the drug in the matrix. Effective skin permeation rate across the hairless mouse skin was obtained from a patch with 1.5 mm thickness and 15% w/w loading dose. n-Decylmethyl sulfoxide and Azone were found to produce an effective skin permeation rate of methadone through human cadaver skin at a 5% w/w concentration. These initial studies demonstrated the feasibility of methadone administration through intact skin from a transdermal patch. |
| Databáze: | OpenAIRE |
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