Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors
| Autor: | Tarcília Aparecida Silva, Elismauro Francisco Mendonça, Aline Carvalho Batista, Débora P. Sousa, Flávia Reis Andrade, Vanessa Soares Lara |
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| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Alveolar Bone Loss Osteoclasts Odontogenic Tumors Osteolysis Bone resorption Odontogenic myxoma Young Adult Osteoprotegerin Internal medicine medicine Humans General Dentistry biology Receptor Activator of Nuclear Factor-kappa B Chemistry Adenomatoid odontogenic tumor RANK Ligand Odontogenic tumor medicine.disease Immunohistochemistry Jaw Neoplasms Calcifying epithelial odontogenic tumor Endocrinology Otorhinolaryngology RANKL Cancer research biology.protein Surgery Female Oral Surgery |
| Zdroj: | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 106(4) |
| ISSN: | 1528-395X |
| Popis: | Objective To investigate the expression of bone resorption regulators (receptor activator of nuclear factor kappa B [RANK], RANK ligand [RANKL], and osteoprotegerin [OPG]) in calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), odontogenic myxoma (OM), and ameloblastic fibroma (AF). Study design The expression of these mediators was evaluated by means of immunohistochemistry. Results All specimens demonstrated positive immunoreactivity to RANK, RANKL, and OPG. The quantification of these mediators in epithelium revealed a similar pattern of expression for RANKL and OPG in CCOT, AOT, CEOT, and AF. With regard to stromal/mesenchymal cells, the majority of AOT and CCOT cases showed a higher content of OPG than RANKL, whereas CEOT, OM, and especially AF had a tendency to present a greater content of RANKL than OPG. Conclusion Our data indicate that the CCOT, AOT, CEOT, OM, and AF cell constituents express key regulators of bone metabolism that might locally modulate tumor-associated bone resorption. |
| Databáze: | OpenAIRE |
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