Upregulated tissue expression of T helper (Th) 17 pathogenic interleukin (IL)-23 and IL-1β in Hashimoto’s thyroiditis but not in Graves’ disease
| Autor: | Ieva Kalere, Valerija Groma, Ilze Konrade, Sandra Skuja, Tatjana Zake |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Graves' disease medicine.medical_treatment Interleukin-1beta 030209 endocrinology & metabolism Hashimoto Disease Interleukin-23 Thyroiditis Pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Interleukin 23 Humans Aged Goiter business.industry Interleukin-17 Thyroid Thyroidectomy Interleukin Middle Aged medicine.disease Immunohistochemistry Graves Disease medicine.anatomical_structure Thyroid Epithelial Cells 030220 oncology & carcinogenesis Th17 Cells Female Interleukin 17 business |
| Zdroj: | Endocrine Journal. 66:423-430 |
| ISSN: | 1348-4540 0918-8959 |
| Popis: | T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1β are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the association between IL-17 and Th17-promoting cytokines in AITD by studying the immunoexpression patterns of IL-17, IL-23, and IL-1β in thyroid tissue. Following thyroidectomy, 29 patients with AITD (21 cases of Hashimoto's thyroiditis (HT) and 8 cases of Graves' disease (GD)) and 18 patients with colloid goiter, as controls, were enrolled in this study, and immunohistochemistry was performed. The expression level of IL-17 in thyrocytes was significantly higher in HT and GD patients than in colloid goiter patients. Immunopositivity for both IL-23 and IL-1β was significantly increased in HT patients compared to GD and colloid goiter patients. However, no difference was found between IL-23 or IL-1β expression in patients with GD and colloid goiter. A positive correlation between IL-17 and IL-23 as well as IL-17 and IL-1β expression was observed in HT patients (r = 0.574, p = 0.007 and r = 0.461, p = 0.036, respectively). In the GD group, IL-17 was positively correlated with IL-1β (r = 0.817, p = 0.013) but not with IL-23 expression. We found increased IL-23 and IL-1β expression in the HT group but not in the GD group. Furthermore, both interleukins were correlated with IL-17 immunopositivity in thyroid tissue, suggesting that pathogenic Th17-promoting cytokines may play a role in HT pathogenesis. |
| Databáze: | OpenAIRE |
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