Turner’s Syndrome in Adulthood
| Autor: | M. Elsheikh, G. S. Conway, J. A. H. Wass, David B. Dunger |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Pediatrics endocrine system diseases Gastrointestinal Diseases Endocrinology Diabetes and Metabolism Osteoporosis Turner Syndrome 030209 endocrinology & metabolism Disease Biology Skin Diseases Short stature Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine Endocrinology Hypothyroidism Quality of life Neoplasms Internal medicine Turner syndrome medicine Humans Ear Diseases X chromosome Aortic dissection Genitalia Female medicine.disease 030104 developmental biology Cardiovascular Diseases Life expectancy Female Kidney Diseases medicine.symptom Cognition Disorders |
| Zdroj: | Endocrine Reviews. 23:120-140 |
| ISSN: | 1945-7189 0163-769X |
| DOI: | 10.1210/edrv.23.1.0457 |
| Popis: | Turner’s syndrome is the most common chromosomal abnormality in females, affecting 1:2,500 live female births. It is a result of absence of an X chromosome or the presence of a structurally abnormal X chromosome. Its most consistent clinical features are short stature and ovarian failure. However, it is becoming increasingly evident that adults with Turner’s syndrome are also susceptible to a range of disorders, including osteoporosis, hypothyroidism, and renal and gastrointestinal disease. Women with Turner’s syndrome have a reduced life expectancy, and recent evidence suggests that this is due to an increased risk of aortic dissection and ischemic heart disease. Up until recently, women with Turner’s syndrome did not have access to focused health care, and thus quality of life was reduced in a significant number of women. All adults with Turner’s syndrome should therefore be followed up by a multidisciplinary team to improve life expectancy and reduce morbidity. |
| Databáze: | OpenAIRE |
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