CGRP stimulates the adhesion of leukocytes to vascular endothelial cells
| Autor: | Giora Z. Feuerstein, Anthony J. Arleth, Pradip K. Bhatnagar, Paul G. Lysko, Nambi Aiyar, Cheng-Po Sung |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Umbilical Veins
Time Factors Endothelium Neutrophils Physiology Calcitonin Gene-Related Peptide Neuropeptide Calcitonin gene-related peptide Biology Biochemistry Umbilical vein Cellular and Molecular Neuroscience Endocrinology Cell Adhesion Cyclic AMP medicine Humans Platelet Activating Factor Cells Cultured Dose-Response Relationship Drug integumentary system U937 cell Tumor Necrosis Factor-alpha Cell adhesion molecule Thrombin Cell biology medicine.anatomical_structure nervous system Calcitonin Immunology Oxygenases Endothelium Vascular Blood vessel |
| Zdroj: | Peptides. 13:429-434 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/0196-9781(92)90071-a |
| Popis: | Calcitonin gene-related peptide (CGRP) stimulates the adhesiveness of human umbilical vein endothelial cells for U937 cells and human neutrophils in a dose- and time-dependent manner. The onset of CGRP-induced adhesives of HUVEC was rapid (30 min), independent of protein synthesis, and lasted over 24 h in the continuous presence of the peptide. The stimulatory effect of CGRP was completely blocked by the CGRP antagonist, CGRP(8–37). The present study provides evidence in support of the potential role of sensory nerve-derived neuropeptides in the modulation of leukocyte adhesion to vascular endothelial cells. |
| Databáze: | OpenAIRE |
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