The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention

Autor: Linda M. Delahanty, Thomas A. Wadden, Pamela J. Goodwin, Catherine M. Alfano, Cynthia A. Thomson, Melinda L. Irwin, Marian L. Neuhouser, Tracy E. Crane, Elizabeth Frank, Patricia A. Spears, Bonnie P. Gillis, Dawn L. Hershman, Electra D. Paskett, Judith Hopkins, Vanessa Bernstein, Vered Stearns, Julia White, Clifford Hudis, Eric P. Winer, Lisa A. Carey, Ann H. Partridge, Jennifer A. Ligibel
Rok vydání: 2021
Předmět:
Zdroj: Obesity (Silver Spring)
ISSN: 1930-739X
1930-7381
Popis: The Breast Cancer Weight Loss (BWEL) trial, is a randomized, controlled trial designed to determine whether weight loss after breast cancer diagnosis can reduce the risk of cancer recurrence in women with overweight or obesity. BWEL will compare the efficacy of a telephone-based, weight loss intervention plus health education materials versus health education materials alone on invasive disease-free survival in 3181 women with stage II-III breast cancer and a body mass index (BMI) >27 kg/m(2). In this report, we provide a detailed description of the goals and methods of the lifestyle intervention and the evidence supporting the intervention used in the BWEL trial. The intervention’s primary goal for participants is to achieve and maintain a weight loss of ≥ 10% of baseline weight through increased physical activity and caloric restriction. The evidence supporting the diet, physical activity and behavioral components of this telephone-based weight loss intervention as well as strategies to promote participant engagement and retention are described. The intervention is provided through 42 sessions, delivered by trained health coaches, over a 2-year period. If the BWEL lifestyle intervention is successful in improving cancer outcomes, then weight loss will be incorporated into the care of thousands of breast cancer patients.
Databáze: OpenAIRE
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