EFFECTS OF REPEATED EXPOSURE OF RATS TO JP-5 OR JP-8 JET FUEL VAPOR ON NEUROBEHAVIORAL CAPACITY AND NEUROTRANSMITTER LEVELS
| Autor: | John Rossi, Glenn D. Ritchie, Alan F. Nordholm, Robert L. Carpenter, Willie Malcomb |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Reflex Startle Serotonin medicine.medical_specialty Dopamine Health Toxicology and Mutagenesis Metabolite Motor Activity Toxicology Time Rats Sprague-Dawley chemistry.chemical_compound Blood serum Internal medicine Avoidance Learning medicine Animals Maze Learning Neurotransmitter Pain Measurement Inhalation exposure Inhalation Exposure Neurotransmitter Agents Behavior Animal Body Weight Homovanillic acid Neurotoxicity Brain Homovanillic Acid Neural Inhibition Hydroxyindoleacetic Acid medicine.disease Hydrocarbons Rats Endocrinology chemistry Anesthesia Toxicity Room air distribution 3 4-Dihydroxyphenylacetic Acid Muscle Contraction |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 63:397-428 |
| ISSN: | 1087-2620 1528-7394 |
| DOI: | 10.1080/152873901300343452 |
| Popis: | The U.S. Naval Service is anticipating transition from the nearly exclusive use of JP-5 jet fuel to predominant use of JP-8, consistent with the primary utilization by the U.S. Army, U.S. Air Force, and the militaries of most NATO countries. To compare the relative risk of repeated exposure to JP-5 versus JP-8 vapor, groups of 32 male Sprague-Dawley rats each were exposed for 6 h/d, 5 d/wk for 6 wk (180 h) to JP-8 jet fuel vapor (1,000 +/- 10% mg/m3), IP-5 vapor (1,200 +/- 10% mg/m3), or room air control conditions. Following a 65-d rest period, rats completed 10 tests selected from the Neurobehavioral Toxicity Assessment Battery (NTAB) to evaluate changes in performance capacity. Repeated exposure to JP-5 resulted in significant effects on only one test, forelimb grip strength (FGS), while exposure to JP-8 vapor resulted in a significant difference versus controls on appetitive reinforcer approach sensitization (ARAS). Rats were further evaluated for concentrations of major neurotransmitters and metabolites in five brain regions and in the blood serum. Levels of dopamine, the dopamine metabolite dihydroxyphenylacetic acid (DOPAC), and the serotonin metabolite homovanillic acid (HVA) were significantly modulated in various brain regions, as measured 85+ d postexposure. Similarly, serum levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were differentially modulated following JP-8 or JP-5 exposure. Results are compared to previously published research evaluating the neurotoxicity of repeated exposure to other hydrocarbon fuels and solvents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|