Sex difference in the effect of dexamethasone on open-field behavior in rats: gonadal hormones
| Autor: | Justin M. Joffe, James A. Mulick, Jasenka Paunović, John M. Peterson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Testosterone propionate
Male endocrine system medicine.medical_specialty Experimental and Cognitive Psychology Open field Dexamethasone Behavioral Neuroscience chemistry.chemical_compound Sex Factors Corticosterone Internal medicine Adrenal Glands polycyclic compounds medicine Endocrine system Animals Testosterone Castration business.industry Body Weight Ovary Uterus Estrogens Organ Size Rats Endocrinology chemistry Ovariectomized rat Exploratory Behavior Female business hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Physiologybehavior. 16(5) |
| ISSN: | 0031-9384 |
| Popis: | A study was undertaken to determine whether or not the sex differences in the effect of dexamethasone (DEX) on open-field defecation depended on the difference in circulating gonadal hormones in normal male and female rats. The experiment involved ovariectomized females, ovariectomized females given supplementary male hormones, and sham-operated females. In comparison to control groups, all the DEX-treated groups showed a suppression of plasma corticosterone levels, a decrease in weight levels, and reduced adrenal weights. Open-field defecation increased in the DEX-treated female rats but open-field activity was not affected. No differences in behavior or physiological changes were evident between the 3 differently treated groups. These results indicate that sex differences in the response of open-field defecation to DEX-treatment is not the result of sex differences in circulating sex hormones. The response may spring from the organizing effects of the gonadal hormones during the perinatal stage rather than the activating effect of gonadal hormones during adulthood. |
| Databáze: | OpenAIRE |
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