Neuromyelitis optica spectrum disorders may be misdiagnosed as Wernicke's encephalopathy
| Autor: | Youming Long, Linzhan Wu, Fulan Shan, Rong Zhong, Cong Gao, Yongxiang Fan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Pathology Encephalopathy 030218 nuclear medicine & medical imaging Wernicke's encephalopathy Diagnosis Differential 03 medical and health sciences Young Adult 0302 clinical medicine medicine Humans Wernicke Encephalopathy Diagnostic Errors Autoantibodies Retrospective Studies Aquaporin 4 Third ventricle Neuromyelitis optica business.industry General Neuroscience Neuromyelitis Optica Autoantibody Retrospective cohort study General Medicine Middle Aged medicine.disease medicine.anatomical_structure Female sense organs Differential diagnosis business 030217 neurology & neurosurgery |
| Zdroj: | The International journal of neuroscience. 126(10) |
| ISSN: | 1563-5279 |
| Popis: | Purpose: To raise doctors’ attention to the differential diagnosis of neuromyelitis optica spectrum disorders (NMOSD) and Wernicke's encephalopathy (WE). Patients and methods: We extensively reviewed the medical records of 136 patients who had visited our hospital since 2008 and were suspected of having central nervous system demyelinating diseases. Four of those patients had somnolence, electrolyte imbalance and brain lesions around the third ventricle and were included in the study. We tested the serum of the four patients for the presence of aquaporin-4 (AQP4) M23 antibody. Results: All the four patients had positive AQP4 antibody in their serum. Two of the patients were misdiagnosed as WE before AQP4 antibody detection occurred. Conclusions: NMOSD and WE have similar brain lesion locations, histopathological changes and clinical manifestations. It is important to distinguish NMOSD from WE by detecting AQP4 antibody in serum or cerebral spinal fluid. Vitamin B1 should also be administered to the patien... |
| Databáze: | OpenAIRE |
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