TIM-1 regulates macrophage cytokine production and B7 family member expression
| Autor: | Melody L. Woods, Renee M. Hein |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Macrophage colony-stimulating factor
medicine.medical_treatment T cell Immunology Stimulation Nitric Oxide Cell Line Mice medicine Animals Immunology and Allergy Macrophage Hepatitis A Virus Cellular Receptor 1 Macrophage inflammatory protein Membrane Glycoproteins Interleukin-6 Tumor Necrosis Factor-alpha Chemistry Macrophages Programmed Cell Death 1 Ligand 2 Protein Interleukin-10 Interleukin 10 Cytokine medicine.anatomical_structure B7-1 Antigen Macrophage cytokine production Receptors Virus B7-2 Antigen Peptides |
| Zdroj: | Immunology Letters. 108:103-108 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2006.11.004 |
| Popis: | T-cell immunoglobulin mucin-1 (TIM-1) is associated with the regulation of T helper type 2 (Th2) immune responses and has been associated with asthma susceptibility. Previous studies have shown that administration of TIM-1 results in T cell hyperproliferation and increased Th2 cytokine secretion. TIM-1 has also been shown to bind to macrophages, but the effects of TIM-1 administration on macrophage activity have not been assessed. In this study we demonstrate that TIM-1 binds to the mouse macrophage cell line RAW 264.7. Stimulation of the RAW264.7 cells with TIM-1 increases nitric oxide production. A dramatic increase in the pro-inflammatory cytokines TNF-alpha and IL-6 is seen upon TIM-1 stimulation of RAW 264.7 cells. Additionally, there is a moderate increase in the immuno-modulatory cytokine IL-10 when RAW 264.7 cells are stimulated with TIM-1. TIM-1 stimulation also alters the expression of some members of the B7 family of co-stimulatory/co-inhibitory proteins. TIM-1 stimulation leads to increased B7-1, B7-H1, and PD-L2 expression, while inhibiting B7-H2 expression. These studies suggest that TIM-1 can regulate macrophage activation and alter the co-stimulatory properties of macrophages and thus may contribute to allergic inflammatory diseases such as asthma. |
| Databáze: | OpenAIRE |
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