A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing
| Autor: | Enrique Martin-Blanco, Antonio Baonza, J.B. Duffy, Fernando Roch, Norbert Perrimon, E. Noll |
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| Rok vydání: | 1999 |
| Předmět: |
MAPK/ERK pathway
Cell type animal structures Cellular differentiation Gene Expression Nerve Tissue Proteins Biology Downregulation and upregulation Animals Drosophila Proteins Wings Animal Eye Proteins Receptors Invertebrate Peptide Molecular Biology Decapentaplegic Rhomboid Pupa Membrane Proteins Cell Differentiation Anatomy Cell biology ErbB Receptors Proto-Oncogene Proteins c-raf Drosophila melanogaster Insect Proteins Mitogen-Activated Protein Kinases Signal transduction Protein Kinases Drosophila Protein Signal Transduction Developmental Biology |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.126.24.5739 |
| Popis: | The Drosophila EGF receptor (DER) is required for the specification of diverse cell fates throughout development. We have examined how the activation of DER controls the development of vein and intervein cells in the Drosophila wing. The data presented here indicate that two distinct events are involved in the determination and differentiation of wing cells. (1) The establishment of a positive feedback amplification loop, which drives DER signaling in larval stages. At this time, rhomboid (rho), in combination with vein, initiates and amplifies the activity of DER in vein cells. (2) The late downregulation of DER activity. At this point, the inactivation of MAPK in vein cells is necessary for the maintenance of the expression of decapentaplegic (dpp) and becomes essential for vein differentiation. Together, these temporal and spatial changes in the activity of DER constitute an autoregulatory network that controls the definition of vein and intervein cell types. |
| Databáze: | OpenAIRE |
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