Endothelin Signaling in Bone
| Autor: | Jasmin Kristianto, Rafia Afzal, Michael G. Johnson, Robert D. Blank |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Bone Neoplasms Bone matrix Biology Bone and Bones Article 03 medical and health sciences 0302 clinical medicine Endocrinology Mediator Osteogenesis Internal medicine Small peptide medicine Humans Receptor Endothelin-1 Wnt signaling pathway 030104 developmental biology Signal transduction Endothelin receptor Neuroscience 030217 neurology & neurosurgery Signal Transduction Hormone |
| Zdroj: | Endocrinology and Metabolism Clinics of North America. 46:51-62 |
| ISSN: | 0889-8529 |
| Popis: | The endothelin (ET) system includes 3 small peptide hormones and a pair of G-protein-coupled receptors. This review first outlines the ET signaling pathway and ET metabolism. Next, it summarizes the role of ET1 signaling in craniofacial development. Then, it discusses observations relating ET signaling to osteoblastic and other osteosclerotic processes in cancer. Finally, it describes recent work in our laboratory that points to endothelin signaling as an upstream mediator of WNT signaling, promoting bone matrix synthesis and mineralization. It concludes with a statement of some remaining gaps in knowledge and proposals for future research. |
| Databáze: | OpenAIRE |
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