NK cell activation: distinct stimulatory pathways counterbalancing inhibitory signals
| Autor: | Alexander B. H. Bakker, Jun Wu, Lewis L. Lanier, Joseph H. Phillips |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Immunology
Cell Inhibitory postsynaptic potential Major histocompatibility complex Lymphocyte Activation Mice Antigens CD Signaling Lymphocytic Activation Molecule Family Immunoreceptor tyrosine-based activation motif MHC class I medicine Immunology and Allergy Animals Humans Tyrosine Receptors Immunologic Receptor Adaptor Proteins Signal Transducing Membrane Glycoproteins biology Effector Histocompatibility Antigens Class I Membrane Proteins General Medicine Cell biology Killer Cells Natural medicine.anatomical_structure Biochemistry biology.protein Tumorimmunology |
| Zdroj: | Human Immunology, 61, 18-27 Human Immunology, 61, 1, pp. 18-27 |
| ISSN: | 0198-8859 |
| Popis: | A delicate balance between positive and negative signals regulates NK cell effector function. Activation of NK cells may be initiated by the triggering of multiple adhesion or costimulatory molecules, and can be counterbalanced by inhibitory signals induced by receptors for MHC class I. A common pathway of inhibitory signaling is provided by immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic domains of these receptors which mediate the recruitment of SH2 domain-bearing tyrosine phosphate-1 (SHP-1). In contrast to the extensive progress that has been made regarding the negative regulation of NK cell function, our knowledge of the signals that activate NK cells is still poor. Recent studies of the activating receptor complexes have shed new light on the induction of NK cell effector function. Several NK receptors using novel adaptors with immunoreceptor tyrosine-based activation motifs (ITAMs) and with PI 3-kinase recruiting motifs have been implicated in NK cell stimulation. |
| Databáze: | OpenAIRE |
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