Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes
| Autor: | E N Knyazev, M. Yu. Shkurnikov, A. G. Tonevitskii, Daniel Wicklein, Timur R. Samatov, Udo Schumacher |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
L1 medicine.drug_class Gene Expression Neural Cell Adhesion Molecule L1 Biology Monoclonal antibody General Biochemistry Genetics and Molecular Biology Small hairpin RNA 03 medical and health sciences 0302 clinical medicine Antigen Antigens Neoplasm Cell Line Tumor medicine Humans Melanoma Wnt Signaling Pathway neoplasms Gene Wnt signaling pathway LRP6 General Medicine medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Cancer research |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 160:807-810 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial-mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE). |
| Databáze: | OpenAIRE |
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