Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity
| Autor: | Quoc Bao Vo, Lien Anh Ha Do, Anh Tuan Tran, Ngoc Quang Minh Ngo, Khanh Le, Nguyen Anh Tran Dac, Hong Nhien Trinh, Jeremy Farrar, Thanh Vu Vo, Bao Tinh Le Binh, Quang Tung Thai, Lu Viet Ho, Thi Thu Loan Tran, Juliet E. Bryant, Thi Dang, Minh Tien Nguyen, Quynh Huong Tran, Thu Van Tran, H. Rogier van Doorn, Bach Hue Nguyen, Thi Thanh Hai Nguyen, Menno de Jong, Ngoc Huong Cao |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Schildgen, O |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Viral Diseases Multivariate analysis Pulmonology viruses Fevers lcsh:Medicine Pathology and Laboratory Medicine medicine.disease_cause Families 0302 clinical medicine Risk Factors Epidemiology Medicine and Health Sciences 030212 general & internal medicine lcsh:Science Prospective cohort study Respiratory Tract Infections Children Multidisciplinary Respiratory tract infections virus diseases Viral Load respiratory system 3. Good health Infectious Diseases Vietnam Child Preschool Seasons Rhinovirus Viral load Research Article medicine.medical_specialty 030106 microbiology Respiratory Syncytial Virus Infections Rhinovirus Infection Microbiology Virus 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Virology Internal medicine medicine Humans Demography business.industry lcsh:R Infant Biology and Life Sciences Age Groups Respiratory Syncytial Virus Human Co-Infections Respiratory Infections People and Places Immunology Earth Sciences Etiology Population Groupings lcsh:Q business Viral Transmission and Infection |
| Zdroj: | PLOS ONE PLoS ONE, Vol 11, Iss 8, p e0160606 (2016) PLoS ONE PLoS ONE, 11(8). Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | Background Despite a high burden of respiratory syncytial virus (RSV) infections among children, data on demographic and clinical characteristics of RSV are scarce in low and middle income countries. This study aims to describe the viral etiologies, the demographic, epidemiological, and clinical characteristics of children under two years of age who were hospitalized with a lower respiratory tract infections (LRTI), focusing on RSV (prevalence, seasonality, subgroups, viral load) and its association with disease severity. Methods A prospective study among children under two years of age, hospitalized with LRTI was conducted in two referral pediatric hospitals in Ho Chi Minh City, Vietnam, from May 2009 to December 2010. Socio-demographic, clinical data and nasopharyngeal swabs were collected on enrolment and discharge. Multiplex real-time RT-PCR (13 viruses) and quantitative RSV RT-PCR were used to identify viral pathogens, RSV load and subgroups. Results Among 632 cases, 48% were RSV positive. RSV infections occurred at younger age than three other leading viral infections i.e rhinovirus (RV), metapneumovirus (MPV), parainfluenza virus (PIV-3) and were significantly more frequent in the first 6 months of life. Clinical severity score of RSV infection was significantly higher than PIV-3 but not for RV or MPV. In multivariate analysis, RV infection was significantly associated with severity while RSV infection was not. Among RSV infections, neither viral load nor viral co-infections were significantly associated with severity. Young age and having fever at admission were significantly associated with both RSV and LRTI severity. A shift in RSV subgroup predominance was observed during two consecutive rainy seasons but was not associated with severity. Conclusion We report etiologies, the epidemiological and clinical characteristics of LRTI among hospitalized children under two years of age and risk factors of RSV and LRTI severity. |
| Databáze: | OpenAIRE |
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