Biomaterials-based Approaches for Cardiac Regeneration
| Autor: | Justin Zhou, Jeffrey Chen, Peter V. Johnston, Samhita Vasu, Deok Ho Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
business.industry Bioactive molecules Injectable hydrogels Heart failure Extracellular vesicles Bioinformatics Clinical trial Cardiac regeneration Cardiovascular diseases Tissue engineering Internal Medicine Medicine State of the Art Review Cardiology and Cardiovascular Medicine business |
| Zdroj: | Korean Circulation Journal |
| ISSN: | 1738-5520 |
| Popis: | Author's summary Cardiovascular disease is a prevalent cause of mortality and morbidity, largely due to the limited ability of cardiomyocytes to proliferate. Existing therapies for cardiac regeneration include cell-based therapies and bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having significant clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in improving cardiac function, promoting angiogenesis, and reducing adverse immune response in both human clinical trials and animal studies. These advances in therapeutic delivery via extracellular vesicles, cardiac patches, and hydrogels have the potential to enable clinical impact of cardiac regeneration therapies. The limited ability of cardiomyocytes to proliferate is a major cause of mortality and morbidity in cardiovascular diseases. There exist therapies for cardiac regeneration that are cell-based as well as that involve bioactive molecules. However, delivery remains one of the major challenges impeding such therapies from having clinical impact. Recent advancements in biomaterials-based approaches for cardiac regeneration have shown promise in clinical trials and animal studies in improving cardiac function, promoting angiogenesis, and reducing adverse immune response. This review will focus on current clinical studies of three contemporary biomaterials-based approaches for cardiac regeneration (extracellular vesicles, injectable hydrogels, and cardiac patches), remaining challenges and shortcomings to be overcome, and future directions for the use of biomaterials to promote cardiac regeneration. |
| Databáze: | OpenAIRE |
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