Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation
| Autor: | K J Hogg, J D Gemmill, P D MacIntyre, W S Hillis, B Bhargava |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pulmonary Circulation Cardiac output Indoles Injections Subcutaneous Hemodynamics Coronary circulation Cerebral circulation Coronary Circulation Physiology (medical) medicine.artery medicine Humans Vasoconstrictor Agents Sulfonamides medicine.diagnostic_test Sumatriptan business.industry Reproducibility of Results Digital subtraction angiography Middle Aged Coronary Vessels medicine.anatomical_structure Anesthesia Blood Circulation Pulmonary artery Female Cardiology and Cardiovascular Medicine business Artery medicine.drug |
| Zdroj: | Circulation. 87:401-405 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.87.2.401 |
| Popis: | BACKGROUND Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. Recent in vitro experiments suggest that it has vasoactive properties in vascular beds distinct from the cerebral circulation. The object of this study was to assess the vasoactive effects of the standard 6-mg subcutaneous dose of sumatriptan used in migraine on the systemic and pulmonary circulations and the coronary artery vasculature. METHODS AND RESULTS Ten patients undergoing diagnostic coronary arteriography were studied with digital subtraction angiography and invasive hemodynamic monitoring. After subcutaneous injection of sumatriptan, there was no significant change in heart rate or ECG morphology. There was a significant rise in the systemic (20%, p < 0.05 by ANOVA) and pulmonary artery (40%, p < 0.05 by ANOVA) pressures. There was no change in cardiac output, but there was a significant increase in total systemic (27%, p < 0.05) and total pulmonary vascular resistance (40%, p < 0.05). Sumatriptan caused a significant reduction (p < 0.001 by ANOVA) in mean absolute coronary artery diameter, from 4.36 +/- 1.60 mm at baseline to 3.67 +/- 1.49 mm (16%) at 10 minutes and to 3.63 +/- 1.49 mm (17%) at 30 minutes after injection. There were no clinical sequelae. CONCLUSIONS Sumatriptan, a 5HT1 receptor agonist administered by the subcutaneous route, causes a vasopressor response in the systemic and pulmonary arterial circulations and coronary artery vasoconstriction. |
| Databáze: | OpenAIRE |
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