Vesicles bearing gifts: the functional importance of micro-RNA transfer in extracellular vesicles in chronic kidney disease
Autor: | Izabella Z.A. Pawluczyk, Alan Bevington, Karl E. Herbert, Nima Abbasian, James O. Burton |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Kidney Physiology Vesicle Biology medicine.disease Exosomes Microvesicles Cell biology 03 medical and health sciences MicroRNAs 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Gene expression microRNA Nucleic acid medicine Animals Humans Platelet Renal Insufficiency Chronic Kidney disease Signal Transduction |
Zdroj: | American journal of physiology. Renal physiology. 315(5) |
ISSN: | 1522-1466 |
Popis: | Extracellular vesicles (EVs), including microparticles (MPs) and exosomes (EXOs), are derived from a wide range of mammalian cells including blood platelets, endothelial cells, and kidney cells and can be detected in body fluids including blood and urine. While EVs are well established as diagnostic markers under pathophysiological and stress conditions, there is also mounting evidence of their functional significance as vehicles for communication between cells mediated by the presence of nucleic acids, especially microRNAs (miRs), encapsulated in the EVs. miRs regulate gene expression, are transported both in MPs and EXOs, and exert profound effects in the kidney. Here we review current understanding of the links between EVs and miRs, discuss the importance of miRs in kidney disease, and shed light on the role of EVs in transferring miRs through the circulation among the renal, vascular, and inflammatory cell populations that are functionally important in patients with chronic kidney disease. |
Databáze: | OpenAIRE |
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