Effect of antipsychotics on serum lithium levels and white blood cell counts
| Autor: | Kenzo Kudo, Tadashi Yoshida, Yukinao Kohda, Takashi Tomita, Ryo Obara, Hidekazu Goto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lithium (medication) medicine.medical_treatment Renal function Micro Reports Lithium Gastroenterology Micro Report chemistry.chemical_compound Leukocyte Count Lithium Carbonate Internal medicine White blood cell Medicine Antipsychotics Humans Pharmacology (medical) Dosing Antipsychotic Chlorpromazine Pharmacology Leukopenia business.industry leukopenia Lithium carbonate chlorpromazine equivalents Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure chemistry medicine.symptom business medicine.drug white blood cell count Antipsychotic Agents |
| Zdroj: | Neuropsychopharmacology Reports |
| ISSN: | 2574-173X |
| Popis: | Lithium carbonate is used to increase white blood cell counts as a means of counteracting leukopenia caused by the administration of antipsychotic drugs. To evaluate the effect of antipsychotics on the leukocyte‐enhancing effect of lithium, we compared white blood cell counts, serum lithium levels, and lithium dosage in patients receiving antipsychotics and lithium in combination and patients receiving lithium alone. Chlorpromazine equivalent values were used as an indicator of the antipsychotic dose. Lithium serum levels were measured in 41 hospitalized patients. The lithium dose in the combination group (median, 800 mg) was significantly higher than that in group receiving only lithium (median, 400 mg) (P = 0.03). The lithium doses in the combination group receiving ≥1000 mg chlorpromazine equivalents (overdosing; median lithium dose 800 mg) and the combination group treated with 600‐999 mg chlorpromazine equivalents (high dosing; median lithium dose 800 mg) were significantly higher than the group that was not treated with antipsychotic medication, with median lithium dose 400 mg (P Effect of chlorpromazine equivalent dose on lithium carbonate dose, serum lithium concentration, and white blood cell count. The lithium doses in the combination group receiving ≥1000 mg chlorpromazine equivalents (overdosing; median lithium dose 800 mg) and the combination group treated with 600‐999 mg chlorpromazine equivalents (high dosing; median lithium dose 800 mg) were significantly higher than the group that was not treated with antipsychotic medication, with median lithium dose 400 mg (P |
| Databáze: | OpenAIRE |
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