A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations
| Autor: | Arezoo Daryadel, Isabel Rubio-Aliaga, Soline Bourgeois, Marko Ugrica, Nicole Gehring, Eva-Maria Pastor-Arroyo, Nati Hernando, Carla Bettoni, Carsten A. Wagner |
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| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Fibroblast growth factor 23 medicine.medical_specialty Calcitriol 030232 urology & nephrology Parathyroid hormone Renal function 610 Medicine & health Bone resorption 10052 Institute of Physiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Bone mineral Transplantation business.industry Phosphate medicine.disease 030104 developmental biology Endocrinology chemistry Nephrology 570 Life sciences biology business medicine.drug Kidney disease |
| Popis: | Background Phosphate intake has increased in the last decades due to a higher consumption of processed foods. This higher intake is detrimental for patients with chronic kidney disease, increasing mortality and cardiovascular disease risk and accelerating kidney dysfunction. Whether a chronic high phosphate diet is also detrimental for the healthy population is still under debate. Methods We fed healthy mature adult mice over a period of 1 year with either a high (1.2% w/w) or a standard (0.6% w/w) phosphate diet, and investigated the impact of a high phosphate diet on mineral homeostasis, kidney function and bone health. Results The high phosphate diet increased plasma phosphate, parathyroid hormone (PTH) and calcitriol levels, with no change in fibroblast growth factor 23 levels. Urinary phosphate, calcium and ammonium excretion were increased. Measured glomerular filtration rate was apparently unaffected, while blood urea was lower and urea clearance was higher in animals fed the high phosphate diet. No change was observed in plasma creatinine levels. Blood and urinary pH were more acidic paralleled by higher bone resorption observed in animals fed a high phosphate diet. Total and cortical bone mineral density was lower in animals fed a high phosphate diet and this effect is independent of the higher PTH levels observed. Conclusions A chronic high phosphate intake did not cause major renal alterations, but affected negatively bone health, increasing bone resorption and decreasing bone mineral density. |
| Databáze: | OpenAIRE |
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