LaeA, a global regulator ofAspergillustoxins

Autor:	Elliot Keats Shwab, Robyn M. Perrin, Jin Woo Bok, Nancy P. Keller, DaWoon Chung
Rok vydání:	2006
Předmět:	Aspergillus biology Gliotoxin Phagocytosis Virulence General Medicine biology.organism_classification Virulence factor Microbiology Aspergillus fumigatus chemistry.chemical_compound Infectious Diseases chemistry medicine Fumagillin Secondary metabolism medicine.drug
Zdroj:	Medical Mycology. 44:83-85
ISSN:	1460-2709 1369-3786
Popis:	Several toxins have been implicated in Aspergillus fumigatus pathogenicity. Among these are gliotoxin, fumagillin, fumagatin, and helvolic acid. Recently we have identified a nuclear protein, LaeA, that regulates the production of all of these metabolites. Several criteria support the role of LaeA as a potent A. fumigatus virulence factor. Among these are a decreased ability of the laeA deletion strain (ΔlaeA) to cause fatal infections in the murine model, increased macrophage phagocytosis of ΔlaeA conidia and decreased ability of ΔlaeA to kill polymorphonuclear neutrophils [1]. Here we present our current knowledge of LaeA function and future directions of study of LaeA mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae11d255d0f107db57871838777ddbb7 https://doi.org/10.1080/13693780600835773 Zobrazit plný text záznamu