Evaluation of Human Papilloma Virus Infection in Patients with Esophageal Squamous Cell Carcinoma from the Caspian Sea Area, North of Iran
| Autor: | Seyed Hamidreza Monavari, Yousef Yahyapour, Sepideh Siadati, Javad Shokri-Shirvani, Mahmoud Mahmoudi, Shefaei Shahryar Shahryar, Mahmoud Shamsi-Shahrabadi, Hamid Mollaei |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Esophageal Neoplasms Epidemiology Iran Biology Esophageal squamous cell carcinoma Esophagus medicine Humans Human papilloma virus infection In patient Papillomaviridae Aged Aged 80 and over Chi-Square Distribution Papillomavirus Infections Public Health Environmental and Occupational Health HPV infection Middle Aged medicine.disease medicine.anatomical_structure Anatomical sites Real-time polymerase chain reaction Oncology DNA Viral Carcinoma Squamous Cell Female High incidence |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 13:1261-1266 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2012.13.4.1261 |
| Popis: | Introduction: HPV has been found repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, reported detection rates of HPV DNA in these tumors have varied markedly. Differences in detection methods, sample types, and geographic regions of sample origin have been suggested as potential causes of variation. We have reported that infection of HPV DNA in ESCC tumors depends on anatomical sites of esophagus of the patients from Mazandaran, north of Iran. Materials and Methods: HPV DNA was examined in 46 upper, 69 middle and 62 lower third anatomical sites of esophageal squamous cell carcinoma specimens collected from Mazandaran province in north Iran, near the Caspian Littoral as a region with high incidence of ESCC. HPV L1 DNA was detected using Qualitative Real time PCR and MY09/MY11 primers. Results: 28.3% of upper, 29% of middle and 25.8% of lower third of ESCC samples were positive for HPV DNA. 13.6% for males and 14.1% for females were HPV positive in all samples. Conclusions: HPV infection is about one third of ESCC in this area. Findings in this study increase the possibility that HPV is involved in esophageal carcinogenesis. Further investigation with a larger sample size is necessary. |
| Databáze: | OpenAIRE |
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