Immunological analysis of particulate antigens of human leukemia
| Autor: | Rosanna Lee, J. B. G. Kwapinski |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Adult
Human leukemia Immunodiffusion Adolescent Immunology Fluorescent Antibody Technique Spleen Biology Applied Microbiology and Biotechnology Microbiology Inclusion Bodies Viral Antigen Genetics medicine Centrifugation Density Gradient Animals Humans Child Molecular Biology Antigens Viral Aged Leukemia Hexagonal crystal system Immune Sera General Medicine Middle Aged medicine.anatomical_structure Retroviridae Liver Child Preschool Ferritins Electrophoresis Polyacrylamide Gel Autopsy Rabbits |
| Zdroj: | Canadian journal of microbiology. 18(12) |
| ISSN: | 0008-4166 |
| Popis: | Numerous hexagonal virus-like particles were detected in, and isolated from, liver and spleen obtained from eight autopsies of human leukemia, diagnosed as different forms of the disease. These particles were purified by a combination of the continuous particle electrophoresis and isopycnic gradient centrifugation. The purified virus-like particles reacted with rabbit antisera produced against the purified particulate antigens of leukemia but not with the extracts obtained from different "normal" human liver and spleen, as examined by the immunodiffusion and immunoferritin techniques. The experimental evidence indicates a biological association of the particulate antigens with human leukemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|